Ultrastructural organization of the aero-hematic barrier of the lungs of laboratory animals
Zaĭtseva, K.K.; Simonenkova, V.A.; Komar, I.A.
Arkhiv Anatomii Gistologii i Embriologii 89(9): 59-66
1985
ISSN/ISBN: 0004-1947 PMID: 4062582 Document Number: 242807
The ultrastructure of the aero-hematic barrier (AHB) of the lungs has been studied in the mostly used laboratory animals-mice and rats. In 2 clinically sound animals in macroscopically unchanged parts of the lungs certain disorders of rheological blood properties, edema and focal destruction of endotheliocytes and alveolocytes of type 1, local destruction of the thin part of AHB were revealed. The changes revealed in AHB ultrastructure in intact mice and rats are in many respects similar to those developing in the lungs under various extreme influences. Therefore, a wide and thorough investigation of the lung structure in intact animals makes it possible to avoid erroneous conclusions at examining various pulmonary pathology and contributes to a correct estimation of its manifestation degree.