Abnormalities of brain structure and density in schizophrenia
Largen, J.W.; Smith, R.C.; Calderon, M.; Baumgartner, R.; Lu, R.B.; Schoolar, J.C.; Ravichandran, G.K.
Biological Psychiatry 19(7): 991-1013
1984
ISSN/ISBN: 0006-3223 PMID: 6478000 Document Number: 239581
Quantitative and qualitative measures of brain morphology were derived through CT [computed tomography scans using computer-assisted methodology in patients with schizophrenia or schizo-affective psychosis and headache controls. Schizophrenics had significantly higher density of white matter together with greater right vs. left asymmetry in density of white matter than controls. Schizophrenics tended to have larger widths of cortical sulci than headache patients. In schizophrenics no significant differences were found on measures of lateral ventricle (LV) width, LV area, VBR (ventricular/brain ratio) or other measures of ventricular size compared to headache controls. There were no differences between CT scan measures taken in patients with schizophrenia vs. schizo-affective psychosis.