Bacopa monnieri (Brahmi) Prevents Cognitive Deficit by Maintaining CA2/3 VGLUT1 Density of Sub-Chronic Phencyclidine Rat Model of Schizophrenia in Normal Level
Piyabhan, P.; Wetchateng, T.
Journal of the Medical Association of Thailand 99 Suppl. 4: S222-S229
2016
ISSN/ISBN: 0125-2208 PMID: 29926716 Document Number: 11280
Decreased vesicular glutamate transporter type 1 (VGLUT1) has been reported in the brains of both postmortem and animal models of schizophrenia. It indicates the deficit of glutamatergic function which is implicated in the cognitive deficit in schizophrenia. Our previous study investigated that Brahmi can recover the cognitive deficit in schizophrenia by upregulating cerebral VGLUT1 density. However, the neuroprotective effects of Brahmi have not been studied yet. To study the effects of Brahmi on the prevention of cognitive deficit and cerebral VGLUT1 density in sub-chronic phencyclidine (PCP) rat model of schizophrenia. Rats were assigned to three groups; Group-A: Control, Group-B: PCP administration and Group- DR in PCP group was significantly decreased compared with control. This occurred alongside significantly reduced VGLUT1 in prefrontal cortex and CA2/3. Brahmi + PCP group showed a significant increase in DR score compared with PCP alone; however, it was still lower than control. This occurred alongside significant increase in VGLUT1 in CA2/3. Cognitive deficit observed in PCP-administered rats was mediated by VGLUT1 reduction in prefrontal cortex