No effect of garlic extract supplement on serum lipid levels in hypercholesterolemic subjects
Satitvipawee, P.; Rawdaree, P.; Indrabhakti, S.; Ratanasuwan, T.; Getn-gern, P.; Viwatwongkasem, C.
Journal of the Medical Association of Thailand 86(8): 750-757
2003
ISSN/ISBN: 0125-2208 PMID: 12948274 Document Number: 2388
Objective: The authors assessed the effects of an enteric-coated Thai garlic extract tablet standardized for allicin-releasing potential on serum lipid levels in hypercholesterolemic subjects. Subjects and Method: The authors performed a randomized, double-blind, placebo-controlled trial in 136 hypercholesterolemic subjects (cholesterol concentrations gtoreq5.2 mmol/L; mean age+-SD: 47.0+-6.6 yr). All subjects were given dietary advice to lower fat intake within 4 weeks and were advised to eat normally during the study period. The subjects were randomly assigned to receive an enteric-coated Thai garlic extract tablet once daily (standardized to 1.12% allicin or 5.6 mg/tablet), or placebo after the evening meal for 12 weeks. Seventy subjects (32.9% male; mean age+-SD and BMI of 47.0+-6.6 yr and 24.6+-3.3 kg/m2) received the garlic extract treatment while 66 subjects (37.9% male, mean age+-SD and BMI of 47.0+-6.0 yr and 24.3+-3.4 kg/m2) received placebo. Results: There were no statistically significant changes in serum total cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol after the 12-week treatment as analyzed on repeated measures by analysis of variance. In addition, no changes in plasma glucose, liver and renal functions were found. Conclusions: Treatment with an enteric garlic-coated Thai garlic extract and dietary advice did not produce any significant changes in lipid levels in subjects with hypercholesterolemia.
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