No expression of human leukocyte antigen G (HLA-G) in colorectal cancer cells
Leelawat, K.; Engprasert, S.; Pongchai-rerk, U.; Tuchinda, S.; Suthipintawong, C.; Leardkamolkarn, V.
Journal of the Medical Association of Thailand 87(7): 816-818
2004
ISSN/ISBN: 0125-2208 PMID: 15521238 Document Number: 2389
Although there is a specific antitumor immune response in the body, colorectal cancer cells progressively develop. This fact indicated that the cancer cells could have a variety of mechanisms to evade or escape the immune system. HLA-G is identified to inhibit the recognition of NK-cell in various kinds of cancers. This study investigated the expression of HLA-G in colorectal cancer. Eighty five specimens of colorectal cancer, carcinoma in situ and adenomatous polyp were examined by immunohistochemistry and RT-PCR for the detection of human leukocyte antigen (HLA)-G The expression of HLA-G was not found in all colorectal specimens (85/85) both protein level and transcription level, suggesting that the expression of HLA-G is not a possible immune evasion mechanism of colorectal cancer cell.
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