Tissue reaction after subcutaneous injection of Taenia saginata oncospheres
Blazek, K.; Schramlová, J.; Danĕk, J.
Folia Parasitologica 31(4): 319-324
1984
ISSN/ISBN: 0015-5683 PMID: 6510835 Document Number: 238062
After subcutaneous injection of T. saginata oncospheres, into 3 male calves a slight swelling is visible at the site of injection 1st after 13 days. Conspicuous projecting nodes appear after 3-4 wk. Histological examinations of the site of injection revealed the following changes. On days 3 and 4 p.i. edema, focal necrosis and hemorrhage, exudation of leukocytes, activation of monocytes and fibroblasts were detected. On day 7 p.i., in addition to edema and foci of eosinophiles, a striking activation of monocytes and fibroblasts, focal accumulation of macrophages, proliferation of blood capillaries and formation of collagen was discovered. On day 10 p.i., eosinophiles and light macrophages were around the larvae; fibroplastic granulation tissue at the periphery and collagenous connective tissue were abundant. Hyperplasia of lymphoid tissue starts to appear at this time. On days 13-14 p.i., a large amount of newly formed connective tissue in granulation tissue, diffuse infiltration of eosinophiles and hyperplasia of lymphatic tissue was seen. On days 19-34 p.i., hemorrhage around the cysticerci, activation of macrophages and phagocytizing erythrocytes were visible. Endothelia of blood capillaries proliferate; lymphatic follicles are formed at the periphery of nodular affection which appears after inoculation of oncospheres. On day 34 p.i. there was a distinct formation of a pseudocyst. At the period from 53-61st day after injection, there was a mature collagenous connective tissue among the cysts, but still strongly in infiltrated with cells. Clusters of siderophages are visible in connective tissue septa between the cysts.