Changes in the ganglioside composition of various rat organs under the action of thyroid hormones
Saatov, T.S.; Burkhanov, S.A.; Usmanova, G.U.
Biokhimiia 49(8): 1291-1294
1984
ISSN/ISBN: 0320-9725 PMID: 6498236 Document Number: 237597
The ganglioside content in various organs of the rat were studied under normal conditions and under deficiency of thyroid hormones. The minimal ganglioside content was observed in skeletal muscles, the maximal one--in the brain. Using thin-layer chromatography, it was demonstrated that these organs possess a complex ganglioside composition which differs both qualitatively and quantitatively. Under thyroid hormone excess, the total ganglioside content shows a tendency to increase, while under hormone deficiency--to decrease. The nature of changes in individual ganglioside fractions in various tissues depends on the thyroid hormone content in the organism.