Changes underlying halothane-induced malignant hyperpyrexia in Landrace pigs
Berman, M.C.; Harrison, G.G.; Bull, A.B.; Kench, J.E.
Nature 225(5233): 653-655
1970
ISSN/ISBN: 0028-0836 PMID: 5413377 Document Number: 23635
Thiopentone induced anaesthesia with no untoward effects in susceptible pigs. Within 10 min. (usually 3-4 min.) of introducing 3% halothane (for a total of 8 min.) the temp. of all organs, except the skin, rose. A maximum core temp. (oesophagus) was reached at 30-45 min. The biochemical changes, which included the shift of Ca and Mg into the extracellular fluids and the production of inorganic phosphate and lactate, preceded the rise in temp. and indicated massive uncontrolled glycogenolysis.