Penetration kinetics of potential virustatics into the human skin
Wohlrab, W.; Helbig, B.; Klöcking, R.; Sprössig, M.
Die Pharmazie 39(8): 562-564
1984
ISSN/ISBN: 0031-7144 PMID: 6504982 Document Number: 236030
Caffeic acid oxidation product (KOP), a substance effective against various human viruses, penetrates quickly from a 1% W/O-emulsion into the skin and forms a reservoir in the horny layer. In the epidermis and dermis approximately 30 min after external application KOP concentrations of 1 to 3% of the applied total quantity are achieved, which remain nearly unchanged even after longer penetration time. In addition to references for therapy derivable from this the results permit to draw conclusions about drug resorption that can be proved in animal experiments under in-vivo conditions.