Beta 2-Microglobulin and other low molecular weight proteins in haemodiafiltrates and in haemofiltrates
Montali, U.; Pilone, N.; Cioni, L.; Ronca, G.
International Journal of Tissue Reactions 6(1): 71-74
1984
ISSN/ISBN: 0250-0868 PMID: 6370888 Document Number: 235121
Uremic patients underwent hemodialysis by cuprophan membrane, or hemodiafiltration by polyacrylonitrile membrane or hemofiltration by acetate cellulose membrane. Plasma samples drawn before and after treatment with the dialyzer were gel-filtered on Sephadex G-75. A comparison of the chromatograms showed that the treatment causes a removal of middle molecules, which is more consistent when hemodiafiltration and hemofiltration are used. Protein removal was examined in the fluids from the 3 dialyzers. Proteins (300 .+-. 45 mg and 410 .+-. 60 mg, respectively) were removed when polyacrylonitrile and acetate cellulose membranes were used, but not in the case of cuprophan membrane. .beta.2-Microglobulin was the protein lost in the greatest amount.