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Use of a radioimmune method for determining HBsAg in preparations of human gamma-globulin

Viazov, S.O.; Bocharova, N.G.; Shalunova, N.V.; Anan'ev, V.A.; Minakova, L.V.

Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 5: 103-105

1984

ISSN/ISBN: 0372-9311
PMID: 6204473
Document Number: 234404
The work presents the results of studies made with a view to improve the method of testing gamma-globulin preparations for the presence of hepatitis B virus surface antigen (HBsAg) by means of radioimmunoassay (RIA). The work shows that this method requires the use of specially selected negative control samples made up of pooled gamma-globulin samples. Standard RIA techniques intended for detecting the presence of HBsAg in human plasma and blood serum is not suitable for the analysis of the preparations of human gamma-globulin.

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