Top Abstract Purchase Related
Home
>
Node
>
Subnode

Interleukin-2 activated peripheral blood lymphocytes and the correlation of lytic activity and peanut agglutinin receptor expression on malignant cells

Gotoh, Y.I.; Minegishi, M.; Yamaguchi, Y.; Konno, T.; Tada, K.

Clinical and Experimental Immunology 57(3): 710-716

1984

ISSN/ISBN: 0009-9104
PMID: 6331930
Document Number: 232699
The possibility that the peanut agglutinin (PNA) receptor and/or its co-ordinate structures on the surface of leukaemia cells might be recognized by lectin free crude interleukin-2 (IL-2) activated human peripheral blood lymphocytes (LAK) was investigated. Analysis was undertaken of the correlation between the sensitivity to allogeneic LAK lysis and the proportion of PNA receptor on different fresh malignant cells. The results obtained suggested that PNA receptor detected by rhodamine isothiocyanate labelled PNA binding assay appeared to be well expressed on leukaemia cells which were sensitive targets for LAK. PNA receptor and/or its coordinate structures seemed to provide a 'target' structure for LAK.

Document emailed within 1 workday
Secure & encrypted payments

Sun, A.; Chu, C.T.; Liu, B.Y.; Wang, J.T.; Leu, J.S.; Chiang, C.P. 2000: Expression of interleukin-2 receptor by activated peripheral blood lymphocytes upregulated by the plasma level of interleukin-2 in patients with recurrent aphthous ulcers Proceedings of the National Science Council Republic of China. Part B Life Sciences 24(3): 116-122
Chen, Y.X. 1990: Expression of interleukin 2(IL-2) receptor and proliferative response to rIL-2 of peripheral blood mononuclear cells (PBMC) in patients with malignant diseases Zhonghua Zhong Liu Za Zhi 12(4): 281-283
Wang, Q.; Zhan, F.-x.; Shan, N.-n.; Hou, M.; Yang, X.-j.; Lu, N.; Wang, H.-c.; Zhang, X.-l.; Ji, X.-b.; Ji, C.-y. 2010: Expression of interleukin-18 and interleukin-18 receptor alpha chain of the peripheral white blood cells in immune thrombocytopenia Zhonghua Nei Ke Za Zhi 49(4): 316-319
Hakim, A.A. 1988: Peripheral blood lymphocytes from patients with cancer lack interleukin-2 (IL-2) receptor expression: isolation of mRNA encoding IL-2R Cancer Detection and Prevention 12(1-6): 59-71
Proudman, S.M.; Cleland, L.G.; Mayrhofer, G. 1999: Effects of tumor necrosis factor-alpha, interleukin 1beta, and activated peripheral blood mononuclear cells on the expression of adhesion molecules and recruitment of leukocytes in rheumatoid synovial xenografts in SCID mice Journal of Rheumatology 26(9): 1877-1889
London, J.; Horton, M.A. 1980: Peanut agglutinin. V. Thymocyte subpopulations in the mouse studied with peanut agglutinin and Ly-6.2 antiserum Journal of Immunology 124(4): 1803-1807
Zhou, X.; Wang, Z.; Lin, Y.; Zhu, Y. 2001: The effects of adenosine, interleukin-1 and theophylline on the expression of A2 adenosine receptor mRNAs in peripheral blood mononuclear cells from asthmatic patients Hua Xi Yi Ke da Xue Xue Bao 32(2): 204-207
Nagel, J.E.; Chopra, R.K.; Powers, D.C.; Adler, W.H. 1989: Effect of age on the human high affinity interleukin 2 receptor of phytohaemagglutinin stimulated peripheral blood lymphocytes Clinical and Experimental Immunology 75(2): 286-291
Bellamy, A.S.; Calder, V.L.; Feldmann, M.; Davison, A.N. 1985: The distribution of interleukin-2 receptor bearing lymphocytes in multiple sclerosis: evidence for a key role of activated lymphocytes Clinical and Experimental Immunology 61(2): 248-256
Mitiushova, E.V.; Shatrova, A.N.; Zenin, V.V.; Aksenov, N.D.; Marakhova, I.I. 2013: The STAT5 signaling in the expression of alpha-subunit of interleukin-2 receptor in human blood lymphocytes Tsitologiia 55(6): 421-429
Wei-Feng, C.; Scollay, R.; Shortman, K. 1982: The functional capacity of thymus subpopulations: limit-dilution analysis of all precursors of cytotoxic lymphocytes and of all T cells capable of proliferation in subpopulations separated by the use of peanut agglutinin Journal of Immunology 129(1): 18-24
Lamers, H.J.; Gratama, J.W.; van Putten, W.L.; Stoter, G.; Bolhuis, R.L. 1991: Exogenous interleukin 2 recruits in vitro lymphokine-activated killer activity by in vivo activated lymphocytes Cancer Research 51(9): 2324-2328
Zanker, B.; Walz, G.; Wieder, K.J.; Moscovitch-Lopatin, M.; Smith, B.R.; Strom, T.B. 1989: Verapamil selectively inhibits expression of interleukin-2 messenger RNA in mitogen activated mononuclear blood cells Transplantation Proceedings 21(1 Part 1): 85-87
Silver, R.M. 1990: Lymphokine activated killer (LAK) cell activity in the peripheral blood lymphocytes of systemic sclerosis (SSc) patients Clinical and Experimental Rheumatology 8(5): 481-486
Itoh, K.; Tilden, A.B.; Kumagai, K.; Balch, C.M. 1985: Leu-11+ lymphocytes with natural killer (NK) activity are precursors of recombinant interleukin 2 (rIL 2)-induced activated killer (AK) cells Journal of Immunology 134(2): 802-807
Murphy, W.J.; Conlon, K.C.; Sayers, T.J.; Wiltrout, R.H.; Back, T.C.; Ortaldo, J.R.; Longo, D.L. 1993: Engraftment and activity of anti-CD3-activated human peripheral blood lymphocytes transferred into mice with severe combined immune deficiency Journal of Immunology 150(8 Pt 1): 3634-3642
Weil-Hillman, G.; Voss, S.D.; Fisch, P.; Schell, K.; Hank, J.A.; Sosman, J.A.; Sugamura, K.; Sondel, P.M. 1990: Natural killer cells activated by interleukin 2 treatment in vivo respond to interleukin 2 primarily through the p75 receptor and maintain the p55 (TAC) negative phenotype Cancer Research 50(9): 2683-2691
Kohn, F.R.; Grigg, M.E.; Klingemann, H.G. 1991: Differential regulation of fibronectin receptor subunit gene and cell surface expression in human peripheral blood T lymphocytes Journal of Immunology 146(5): 1484-1489
Chakraborty, A.; Chakraborty, N.G.; Chattopadhyay, U. 1994: Age related natural killer activity of peripheral blood lymphocytes from healthy subjects and cancer patients. A comparative in vitro study with interleukin-2 Tumori 80(3): 233-237
Kan, H.; Song, W.; Jiang, R. 2001: Effect of airborne fungi on interleukin-4 mRNA expression in the peripheral blood mononuclear cells of rats Wei Sheng Yan Jiu 30(5): 269-270