Tumor markers (alpha 2-macroglobulin, secretory immunoglobulin A, pregnancy-associated alpha 2-glycoprotein) in the serum of patients with bronchial carcinoma
Briese, V.; Willroth, P.O.; Brock, J.; Straube, W.
Archiv für Geschwulstforschung 54(5): 391-398
1984
ISSN/ISBN: 0003-911X PMID: 6208875 Document Number: 231984
Concentration of alpha 2-macroglobulin (AMG), pregnancy associated-alpha 2-glycoprotein (alpha 2-PAG, PZ) secretory immunoglobulin A (S-IgA), pregnancy specific-beta 1-glycoprotein (SP1) and immunoglobulin E (IgE) were estimated in serum samples of 88 patients with lung cancer of stages, II-IV. The proteins were determined by means of the single radial immunodiffusion and the rocket immunoelectrophoresis. AMG and S-IgA serum concentrations of the cancer group compared with those of the control group, were increased significantly. AMG (control group: means = 1,43 g/l; s = 0,999; tumor group: means = 4,37 g/l; s = 1,758); S-IgA (control group: means = 37 mg/l; s = 16,6; tumor group: means = 48 mg/l; s = 24,2). PZ was found only in 52% of the patients with lung cancer by means of the rocket immunoelectrophoresis. The difference between the tumour and the control group was not significant. IgE could be detected only in one case with lung cancer (IgE = 2950 IU/ml). It was not possible to detect SP1 by means of the single radial immunodiffusion in serum samples of lung cancer patients.