Antimuscarinic compounds and gastric kinetics: a study with pirenzepine on healthy subjects
Rinetti, M.; Ugolotti, G.; Ferretti, P.P.; Colombi Zinelli, L.; Alberti, R.
International Journal of Clinical Pharmacology Research 4(2): 145-148
1984
ISSN/ISBN: 0251-1649 PMID: 6547929 Document Number: 231860
A study has been made on the modifications that appear after acute dosage of pirenzepine in a series of eight healthy subjects of both sexes who had shown, by radioisotopic evaluation, a physiological pattern of gastric kinetics. The acute dosage of the drug was continued for three days at therapeutic doses and, a few hours after the last administration, the same study was repeated. As a test meal, a whole fried egg containing 99mTc-labelled serum albumin was used. The kinetics of the gastric content was scanned by a gamma-camera. The difference in gastric kinetics between the baseline situation and that after administration of the drug is reported and discussed.