Effects of antimuscarinic agents, H2-blockers and omeprazole on rat chronic gastric ulcer after long- and short-term administration
Chiavarini, M.; Morini, G.; Barocelli, E.; Impicciatore, M.; Bordi, F.
Il Farmaco; Edizione Scientifica 43(5): 479-487
1988
ISSN/ISBN: 0430-0920 PMID: 2906011 Document Number: 306962
Two series of experiments were performed on rat chronic ulcer in order to assess the possible curative and mucosal protective properties of 2 week treatments, or the preventive properties of 4 week treatments with antisecretory agents, acting with different mechanisms of action. At the end of the treatments the gastric secretory and motor responsiveness to a gastrin-like stimulus was simultaneously evaluated. The results support the view that antimuscarinic agents as well as H2-blockers cannot be defined as protective and that after a 4 week treatment they can induce modifications of gastric functions.