Single dose of tinidazole in the treatment of vaginal discharge
Paavonen, J.; Vesterinen, E.; Purola, E.; Jokipii, A.M.; Jokipii, L.; Holttinen, K.; Vartiainen, E.
Scandinavian Journal of Urology and Nephrology. Supplementum 86: 237-240
1984
ISSN/ISBN: 0300-8886 PMID: 6399407 Document Number: 230913
Unselected women (79) whose main symptom was abnormal vaginal discharge were seen at the Department of Obstetrics and Gynecology at Helsinki University Central Hospital (Finland) between Oct. 1980 and Sept. 1981. All patients and their current sex partners were randomly treated either with a 2-g single dose of tinidazole (effective against anaerobic bacteria) or with identical placebos. Those excluded were 9 patients who did not attend the follow-up examination, 15 who had specific cervicovaginal infections (6 with chlamydial infection, 4 with trichomoniasis and 5 with yeast infection), and 22 with normal Doderlein flora seen on vaginal Pap smear. Response to the treatment was analyzed among the remaining 33 women, of whom 17 received tinidazole and 16 placebo. The symptoms and signs that best discriminated between those who had normal Doderlein flora and those who had non-Doderlein flora were malodor, other than white color of the discharge, and the presence of clue cells on Pap smear. When these findings were used to evaluate the response to treatment, tinidazole proved to be more effective than placebo. Disappearance of clue cells best (P < 0.01) discriminated between tinidazole and placebo.
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