The effect of clidanac, a potent anti-inflammatory drug, on mitochondrial respiration: a consideration on the uncoupling activity of optical enantiomers
Kawai, K.; Shiojiri, H.; Fukushima, H.; Nozawa, Y.; Hasegawa, J.; Nozaki, M.; Tsurumi, K.; Fujimura, H.
Research Communications in Chemical Pathology and Pharmacology 45(3): 399-406
1984
ISSN/ISBN: 0034-5164 PMID: 6334337 Document Number: 230586
The uncoupling activities of clidanac and its dechlorinated derivative on oxidative phosphorylation were examined using isolated rat liver mitochondria. Clidanac was found to uncouple the oxidative phosphorylation and no difference was detected in the uncoupling potency of the two enantiomorphs. Dechlorclidanac was significantly less effective in the uncoupling activity than clidanac.
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