Age-related differences in the effect of osmotic pressure on liver mitochondrial respiration in rats
Udovikova, E.A.; Lemeshko, V.V.
Biulleten' Eksperimental'noi Biologii i Meditsiny 111(2): 150-152
1991
ISSN/ISBN: 0365-9615 PMID: 1854956 Document Number: 385611
The subject under investigation is the influence of osmotic pressure of incubation medium (25-500 mM of sucrose) upon the respiration and the respiration control (RC) of mitochondria of the liver of rats aged 1, 3, 12 and 24 months when oxidizing succinate. In a medium with 0.3 M of sucrose the respiration rate under condition 3 (V3) and RC increased from the age of 1 to 12 months and decreased by 24 months. In a medium with 0.15 M of sucrose the age differences have not been observed. In a uncoupling state the osmotic dependence of the respiration of mitochondria of 1- and 12-month-old rats did not vary. It is assumed that with age there is a change in the rate of structural coupling of the carrier of adenine nucleotides with H(+)-ATP synthetase complex and (or) the viscosity of the matrix.