Cardiac effects of essential phospholipids and prostaglandin release by the heart in the rat
Smirnov, I.E.; Ziabkina, A.G.; Markov, K.M.
Kardiologiia 24(4): 99-104
1984
ISSN/ISBN: 0022-9040 PMID: 6233448 Document Number: 228305
The article deals with the effect of exogenic phospholipids of vegetative origin enriched with polyunsaturated fatty acids (EPL substance) on prostaglandin release and the activity of the isolated, perfused according to Langendorf , heart of Wistar and Okamoto-Aoki rats with congenital arterial hypertension. Exogenic essential phospholipids were shown to facilitate a significant enhancement of endogenic prostaglandin release and to induce a positive inotropic, negative chronotropic and marked coronarodilating effects. These EPL effects were inhibited by indometacin and were considerably altered in rats with spontaneous hypertension. It was concluded that the cardiac effects of essential phospholipids are modulated by elevated prostaglandin secretion. The role of essential phospholipids in the prostaglandin biosynthesis regulation and the cardiac activity of rats is discussed.