Heterogeneity in the phenotypic profile of cerebriform cells from a patient with Sézary syndrome
Fattorossi, A.; Palermo, A.; Quercetani, R.; Reali, U.M.; Battini, M.L.; Giannotti, B.
Tumori 70(6): 507-511
1984
ISSN/ISBN: 0300-8916 PMID: 6531793 Document Number: 228247
Reported are the results of a series of light microscopic, EM, cytochemical, immunologic and cytogenetic investigations performed in a patient with Sezary syndrome. Fifty-two percent of the cerebriform cells were OKIa-1 positive; 55% were acid .alpha.-naphthy acetate esterase (ANAE) negative. Since activated T-lymphocytes are known to lose their peculiar ANAE activity while acquiring Ia-like antigens, it is conceivable that the ANAE-negative and OKIa-1-positive cells represent an in vivo activated subset. It appears that a typical Sezary cell population from a given individual can exhibit heterogeneous phenotypic profiles.