Incidence of chromosome aberrations in the bone marrow of monkeys and their progeny after exposure to aflatoxin B1

Adzhigitov, F.I.; Kosichenko, L.P.; Popandopulo, P.G.; Gubeladze, D.A.; Dzhemilev, Z.A.; Adzhigitov, F.I; Kosichenko, L.P; Popandopulo, P.G; Gubeladze, D.A; Dzhemilev, Z.A

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Incidence of chromosome aberrations in the bone marrow of monkeys and their progeny after exposure to aflatoxin B1

Adzhigitov, F.I.; Kosichenko, L.P.; Popandopulo, P.G.; Gubeladze, D.A.; Dzhemilev, Z.A.

Tsitologiia i Genetika 18(3): 173-176

1984

ISSN/ISBN: 0564-3783

PMID: 6431671

Document Number: 227337

A mutagenic effect of aflatoxin B1 (AFB1) was studied in somatic cells of primates. It is shown that AFB1 elevates the chromosome aberration frequency in bone marrow cells of two monkey species: Macaca mulatta and Papio hamadryas. Genome mutations were found in these experimental primates simultaneously with chromosome aberrations. The AFB1-induced chromosome aberrations were revealed at least during two years of the study. The fact of the chromosome aberration frequency increase was established in Macaca babies born from females who received AFB1 in pregnancy.