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Stable chromosome rearrangements in the somatic cells of monkeys subjected to acute radiation exposure

Kosichenko, L.P.

Genetika 20(5): 835-840

1984

ISSN/ISBN: 0016-6758
PMID: 6539725
Document Number: 238906
Frequencies of stable chromosome rearrangements in bone marrow cells of rhesus monkeys (Macaca mulatta) have been determined for following time periods: from 0.25 to 6.0 and from 10.0 to 18.0 years after gamma-irradiation at doses of 154.8-167.7 mC/kg. The time of the occurrence of pathological clones and the character of their formation in those cells, whose markers were presented by chromosome rearrangements of the same type, have been defined. Some animals showed the tendency towards the increase in the frequency of uni-type rearrangements in the pathological cell clones. This phenomenon could be a potential precursor of the pathological processes in irradiated individuals.

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