Clinical efficacy of cefoperazone in obstetric and gynecologic infections
Ling, F.W.; McNeeley, S.G.; Anderson, G.D.; Buxton, B.H.; Hester, M.G.
Clinical Therapeutics 6(5): 669-676
1984
ISSN/ISBN: 0149-2918 PMID: 6383613 Document Number: 224143
Compared with 2nd-generation cephalosporins, cefoperazone, a 3rd-generation cephalosporin, has demonstrated an extended antibacterial spectrum. It has a long serum half-life and requires only twice-a-day administration. In this study, 66 patients with clinically diagnosed obstetric and gynecologic infections were treated with cefoperazone, and 61 were evaluated for efficacy. An overall cure rate of 93% (57 patients) was achieved. In view of the excellent clinical response and convenience of twice-a-day administration, it was concluded that cefoperazone is a clinically useful single agent for the initial empirical treatment of patients with obstetric and gynecologic infections.