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Clinical studies on cefoperazone treatment for bile duct infections

Hirayama, T.; Kikuchi, K.

Japanese Journal of Antibiotics 34(6): 934-938

1981

ISSN/ISBN: 0368-2781
PMID: 6457179
Document Number: 181685
The clinical effects cefoperazone (CPZ) treatment for 10 patients with bile duct infection were investigated and the following results were obtained. 1. Absorption and excretion of CPZ: CPZ of 500 mg was administered with intravenous one shot injection to 2 patients of which one was malignant tumor case and the remaining was non tumor case. A peak of CPZ level in serum was 63.0 mcg/ml and 54.7 mcg/ml respectively. CPZ level in bile was maximum at 81.5 mcg/ml and 292.5 mcg/ml respectively. 2. Clinical effectiveness: Of 10 patients treated with CPZ, the results were excellent in 2 cases, good in 5 cases and poor in 3 cases. 3. Side effects of CPZ: No significant side effects were observed in these patients except for one case in which rash appeared in whole body.

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