Functional state of cells and intracellular structures exposed to regeneration stimulators at early stages of the membranotropic effect of environmental chemicals
Merkur'eva, R.V.; Bilich, G.L.; Litvinov, N.N.
Biulleten' Eksperimental'noi Biologii i Meditsiny 97(1): 98-100
1984
ISSN/ISBN: 0365-9615 PMID: 6692035 Document Number: 223638
The authors provide the biochemical, morphological and morphometry data on the functions of the cells (alveolar macrophages of the lungs) and intracellular structures (lysosomes, microsomes) of the liver and macrophages from rats exposed to a widely spread carcinogen nitrosodimethylamine and to one of pyrimidine derivatives as a stimulant of regeneration processes. It has been demonstrated that the pyrimidine derivative may prevent the unfavourable metabolic effects occurring at the cellular level (alveolar macrophages of the lungs) and cell organelles (lysosomes and endoplasmic network) in the early stages of the membrane-damaging action of nitrosodimethylamine.