Functional diagnosis of retinal ischemia. Communication 1. Reaction of Muller cells at early stages of diabetic retinopathy
Nevroev, V.V.; Zueva, M.V.; Tsapenko, I.V.; Riabina, M.V.; Hun, L.
Vestnik Oftalmologii 120(6): 11-13
2004
ISSN/ISBN: 0042-465X PMID: 15678661 Document Number: 570538
Electroretinographic examinations were made in 191 patients with non-proliferative and pre-proliferative diabetic retinopathy. On the basis of the ratio of b-wave in ??? and ???? at 12 Hz, the glial index (Cg) was estimated for evaluating the functional changes in Muller cells. As the retinal ischemia aggravated, C@f was increasing, which was indicative of an activated metabolism of Muller cells. C@g was shown to be a sensitive criterion of retinal ischemia ensuring the detection of initial stages of retinal ischemia prior to the detection of changes recognizable in ophthalmoscopy and fluorescence angiography. The established regularities of changing functions in Muller glia and in glia-neuron ratios denote the possibility of using the electroretinographic criteria in the diagnosis of lesions in the retina and of early signs of retinal dystrophy in diabetic retinopathy.