Some pharmacological studies on a new tripeptide mustard
Coppi, G.; Berti, M.A.; Gatti, T.; Mosconi, P.
Il Farmaco; Edizione Scientifica 39(1): 26-34
1984
ISSN/ISBN: 0430-0920 PMID: 6705911 Document Number: 223109
The analgesic, spasmolytic, antiinflammatory, C.N.S., cardiovascular, respiratory, and anaphylactogenic activities of PTT-119 were investigated. PTT-119 possesses good peripheral but only slight central analgesic activity. It presents an interesting in vitro spasmolytic activity of non-competitive type against acetylcholine and histamine. PTT-119 is inactive in rat carrageenin oedema, on the C.N.S. of mice, on cardiovascular and respiratory parameters of cats, and in guinea-pig anaphylaxis.