Hypotensive effect of human factor XIi active fragment in conscious normotensive rats: role of bradykinin
Waeber, B.; Nussberger, J.; Brunner, H.R.; de Agostini, A.; Schapira, M.
Journal of Hypertension. Suppl Official Journal of the International Society of Hypertension 2(3): S341-S342
1984
ISSN/ISBN: 0952-1178 PMID: 6400378 Document Number: 222746
The active fragment derived from factor XII (factor XIIf) was purified from human plasma and administered intravenously to normotensive conscious rats. Factor XIIf-mediated hypotension was dose-dependent and augmented by pretreatment with captopril, an inhibitor of the bradykinin-processing enzyme kininase II. These results therefore suggest that factor XIIf-mediated hypotension is due to the formation of bradykinin.