Influence of corticotropin-releasing factor fragment CRF4-6 on metabolism in rats
Andreev-Andrievskiĭ, A.A.; Andreeva, L.A.; Mart'ianov, A.A.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 98(5): 627-635
2012
ISSN/ISBN: 0869-8139 PMID: 22838197 Document Number: 658659
Influence of corticotropin-releasing factor fragment CRF4-6 on metabolism in the rat was investigated in this study. Tripeptide (10 mkg/rat) after intracerebroventricular infusion to anesthetized animals increased metabolic rate, not affecting the respiratory ratio, induced hyperglycemia and hyperthermia. Synchronously with that heart rate and arterial pressure did also increase. Changes in energy metabolism induced by CRF4-6 closely resemble the effect of untruncated corticotropin-releasing factor molecule. Results of this study and the range of tripeptide effects described previously evidence that CRF4-6 is a physiologically active regulatory molecule, a derivative of corticotropin-releasing factor, that expands and prolongs effects of the parent molecule.