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The effect of antiepileptic drugs on nonesterified fatty acids in the brain structures during convulsive state

Sklenovský, A.; Chmela, Z.

Acta Universitatis Palackianae Olomucensis Facultatis Medicae 106: 47-56

1984

ISSN/ISBN: 0301-2514
PMID: 6242623
Document Number: 222233
In the brain tissue there exists a highly active pool of nonesterified fatty acids (NEFA). The greatest part of NEFA comes from the fraction of nerve endings. The model convulsive activity provoked by Bemegrid increased NEFA in the brain cortex, hypothalamus and brain stem. Antiepileptics.sbd.diazepam, mephenytoin and trimethadione.sbd.markedly decreased the convulsive increase of NEFA. The greatest differences in the effect of antiepileptics were observed in the brain stem. The greatest inhibitory effect was exerted by mephenytoin, the smallest by diazepam. The different level of membrane stabilization of the brain stem may be the cause of differential effect of individual antiepileptics on various types of convulsions.

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Sklenovský, A.; Chmela, Z. 1987: The effect of antiepileptic drugs. II. (Valproate, methsuximide) on nonesterified fatty acids in the brain structures during convulsive state Acta Universitatis Palackianae Olomucensis Facultatis Medicae 117: 125-135
Sklenovský, A.; Chmela, Z. 1984: Nonesterified fatty acids in the brain structures--the effect of convulsive activity Acta Universitatis Palackianae Olomucensis Facultatis Medicae 106: 39-46
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