The influence of prazosin on E. coli lipopolysaccharide-induced fever and noradrenaline hyperthermia
Matuszek, M.; Szreder, Z.
Polish Journal of Pharmacology and Pharmacy 36(6): 585-593
1984
ISSN/ISBN: 0301-0244 PMID: 6398869 Document Number: 221740
We investigated the effect of prazosin on experimental fever induced by E. coli lipopolysaccharide (LPS) and on noradrenaline hyperthermia in the rabbit. LPS and prazosin were administered iv and ivc, noradrenaline was administered only iv. Prazosin inhibited both LPS fever and noradrenaline hyperthermia in a dose-dependent manner. The results indicate the participation of alpha-adrenoceptor in the pyrogen fever and noradrenaline hyperthermia.
Document emailed within 1 workday
Related Documents
Magnuson, D.K.; Weintraub, A.; Pohlman, T.H.; Maier, R.V. 1989: Human endothelial cell adhesiveness for neutrophils, induced by Escherichia coli lipopolysaccharide in vitro, is inhibited by Bacteroides fragilis lipopolysaccharide Journal of Immunology 143(9): 3025-3030Abdullah, A.S.; Baggot, J.D. 1984: Influence of Escherichia coli endotoxin-induced fever on pharmacokinetics of imidocarb in dogs and goats American Journal of Veterinary Research 45(12): 2645-2648
Goldstein, I.; Hadjinsky, P.; Renais, J.; Scebat, L. 1978: Experimental nephropathy induced in the rabbit by immunization with a lipopolysaccharide from Escherichia coli Israel Journal of Medical Sciences 14(8): 882-888
Lapsha, V.I.; Gurin, V.N. 2007: Ultrastructural changes in the right atrium in rats during E. coli lipopolysaccharide-induced systemic inflammation Morfologiia 132(5): 58-62
Paya, D.; Gray, G.A.; Fleming, I.; Stoclet, J.C. 1993: Effect of dexamethasone on the onset and persistence of vascular hyporeactivity induced by E. coli lipopolysaccharide in rats Circulatory Shock 41(2): 103-112
Ellingsen, O.; Kjekshus, J. 1984: Prazosin in exercise-induced angina pectoris. An open study of work capacity after a single dose of prazosin, isosorbide dinitrate, atenolol and nifedipine Tidsskrift for den Norske Laegeforening: Tidsskrift for Praktisk Medicin Ny Raekke 104(9): 657-660
Doggrell, S.A.; Paton, D.M. 1978: Effects of prazosin and phentolamine on responses to field stimulation and to noradrenaline in vas deferens and anococcygeus muscle of the rat Archives Internationales de Pharmacodynamie et de Therapie 233(2): 209-220
Juan, H.; Sutter, D.; Sametz, W. 1987: Influence of eicosapentaenoic acid on noradrenaline and angiotensin-induced contractions of the rabbit aorta: mode of action Progress in Clinical and Biological Research 242: 57-62
Smoliakova, G.P.; Moiseev, V.P. 1986: Morphologic changes in the retina experimentally induced by noradrenaline and combined exposure to noradrenaline and light of moderate intensity Vestnik Oftalmologii 102(5): 43-46
Huk-Kolega, H.; Piechota, A.; Kleniewska, P.; Michalski, Łu.; Goraca, A. 2011: The influence of lipoic acid on total protein concentration in the liver and spleen tissue in rats during lipopolysaccharide-induced oxidative stress Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego 31(184): 212-214
Burns, P.A.; Gordon, A.J.; Kunsmann, K.; Glickman, B.W. 1988: Influence of neighboring base sequence on the distribution and repair of N-ethyl-N-nitrosourea-induced lesions in Escherichia coli Cancer Research 48(16): 4455-4458
Fujii, S.; Takai, M.; Maki, T. 2002: Wet heat inactivation of lipopolysaccharide from E. coli serotype 055:B5 PDA Journal of Pharmaceutical Science and Technology 56(4): 220-227
Mayer, O.; Cepelák, V.; Suchová, H. 1984: Antihypertensive effectiveness of a domestically manufactured preparation of prazosin (Prazosin VUFB) Vnitrni Lekarstvi 30(9): 884-892
Paull, S.A.; Carter, L.; Jackson, G.D. 1988: Immune responses in liver and bile to Escherichia coli 0111:B4 lipopolysaccharide Progress in Clinical and Biological Research 272: 173-184
Caldwell, F.T.; Graves, D.B.; Wallace, B.H. 1999: Humoral versus neural pathways for fever production in rats after administration of lipopolysaccharide Journal of Trauma 47(1): 120-129
Joiner, K.A.; Goldman, R.; Schmetz, M.; Berger, M.; Hammer, C.H.; Frank, M.M.; Leive, L. 1984: A quantitative analysis of C3 binding to O-antigen capsule, lipopolysaccharide, and outer membrane protein of E. coli 0111B4 Journal of Immunology 132(1): 369-375
Von Ardenne, M.; Reitnauer, P.G. 1971: In vitro study for shortening of hyperthermia duration in multi-step cancer therapy. Release of lysosomal cytolysis chain reaction by over-acidification and hyperthermia and its continuation after cessation of hyperthermia Archiv für Geschwulstforschung 38(3): 264-269
Ekimova, I.V. 2002: Changes in metabolic activity of neurons in the anterior hypothalamus nuclei during hyperthermia, fever, and hypothermia Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 88(1): 63-70
Jirillo, E.; Monno, R.; Munno, I.; De Santis, A.; Fumarola, D. 1977: Effects of tilorone hydrochloride on cellular immunity (leukocyte inhibiting factor production from human lymphocyte stimulated by E. coli lipopolysaccharide) Bollettino dell'Istituto Sieroterapico Milanese 56(4): 299-302
Yaqoob, M.; Parys, B.; Ahmad, R. 1991: Prazosin induced priapism in a patient on continuous ambulatory peritoneal dialysis (CAPD) Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 11(4): 363-364