Effects of tilorone hydrochloride on cellular immunity (leukocyte inhibiting factor production from human lymphocyte stimulated by E. coli lipopolysaccharide)
Jirillo, E.; Monno, R.; Munno, I.; De Santis, A.; Fumarola, D.
Bollettino dell'Istituto Sieroterapico Milanese 56(4): 299-302
1977
ISSN/ISBN: 0021-2547 PMID: 334193 Document Number: 110903
Tilorone hydrochloride, a drug able selectively to affect T-lymphocyte fuction, when incorporated (at three different concentrations 0.1, 0.04, 0.02 microgram/ml) in lymphocyte culture, stimulated by 50 microgram/ml of E. coli LPS (026:B6 W), is able to abolish LIF production, due to endotoxin stimulation. Such effect is, may be, due to an impairment of T-cell activity, since tilorone at the same concentration decreases the number of ARFC and TRFC, which are specific markers for T-cells.