The influence of lipoic acid on total protein concentration in the liver and spleen tissue in rats during lipopolysaccharide-induced oxidative stress
Huk-Kolega, H.; Piechota, A.; Kleniewska, P.; Michalski, Łu.; Goraca, A.
Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego 31(184): 212-214
2011
ISSN/ISBN: 1426-9686 PMID: 22097177 Document Number: 652460
To evaluate the influence of lipoic acid on total protein concentration in the liver and spleen in rats during endotoxemia. Experiments were performed on Wistar rats divided into following groups: Group I (control) received saline; Group II (LA) received lipoic acid (60 mg/kg b.w.); Group III (LPS) received lipopolysaccharide (30 mg/kg b.w.); Group IV (LPS+LA) received LPS (30 mg/kg b.w.) and 30 min later LA (60 mg/kg b.w.). Five hours after last injection rats were sacrificed, and the liver and spleen were harvested for subsequent total protein assay. Lipoic acid administration led to a significant increase in total protein concentration in the liver and spleen tissue of endotoxemic rats when compared to control. Lipoic acid administration during early phase of LPS-induced oxidative stress increase protein level in the liver and spleen tissue, which indicate an increase of antioxidant properties of an organism.