Experimental nephropathy induced in the rabbit by immunization with a lipopolysaccharide from Escherichia coli
Goldstein, I.; Hadjinsky, P.; Renais, J.; Scebat, L.
Israel Journal of Medical Sciences 14(8): 882-888
1978
ISSN/ISBN: 0021-2180 PMID: 359504 Document Number: 131518
Twenty rabbits were each injected with 100 microgram of lipopolysaccharide from Escherichia coli 055 at weekly intervals for up to 15 months. The antisera showed an immunologic cross-reactivity with rabbit kidney glycoprotein. A macroscopic nephropathy was present in 14 of the 17 rabbits in which the kidneys were examined. All the rabbits showed extensive histologic lesions involving all the structures of the kidney: organized thrombosis of the arteries, extensive areas of infarction, glomerular atrophy, tubular necrosis and proliferation of young connective tissue. A marked infiltration with lymphoid cells and some plasmacytes was present. The immunologic character of this nephropathy and the immunopathogenic mechanism involved in its pathogenesis are discussed.