Importance of treatment regimen of interferon as an antitumor agent
Lee, S.H.; Chiu, H.; Rinderknecht, E.; Sabo, W.; Stebbing, N.
Cancer Research 43(9): 4172-4175
1983
ISSN/ISBN: 0008-5472 PMID: 6347366 Document Number: 221124
A highly purified hybrid human leukocyte interferon, IFN-.alpha.AD, produced in Escherichia coli, was used to define optimum treatment conditions for L1210 leukemia in mice. Treatments prior to tumor inoculation were ineffective. Treatments from the 3rd day post-tumor inoculation were most effective, and treatments every 3rd day were more effective than were regimens involving more frequent treatments. IFN-.alpha.AD was effective in vivo against tumors formed from a line of L1210 cells resistant to IFN-.alpha.AD in cell cultures. These and other results indicate the importance and nature of indirect mechanisms of action for efficacy of interferons against tumors.