Effect of fentolamin and its combination with etiron on microcirculation
Gikavyĭ, V.I.; Mukhin, E.A.
Farmakologiia i Toksikologiia 46(4): 49-54
1983
ISSN/ISBN: 0014-8318 PMID: 6413246 Document Number: 220339
It has been shown in experiments on rats anesthetized with thiopental that intravenous injection of phentolamine in a dose of 10 mg/kg enlarges the microvessels of the mesoappendix, pia mater, liver and kidneys and raises the number of functioning capillaries. Administration of etiron after phentolamine stabilized AP and corrects microcirculation. The drug raises the tone of the microvessels when applied locally in a dose of 0.15 ml (1 : 5000) or intravenously in a dose of 20 mg/kg. Etiron largely produces the constriction of the distal vessels of the arterial area of the microvascular bloodstream. The diameter of the microvessels diminished to a greater degree after intravenous injection of etiron in the presence of a alpha-adrenoreceptor blockade as compared to local application. The sensitivity of the microvessels to etiron administered after phentolamine is inversely proportional to their diameter. Combined use of etiron with alpha-adrenoblockers considerably widens the possibilities of drug control of the vascular tone.