Effects of aspirin and nifedipine alone or in combination on mesenteric microcirculation of rats
Song, Y.M.; Qin, J.M.; Li, Z.X.; Shi, S.
Zhongguo Yao Li Xue Bao 17(2): 189-192
1996
ISSN/ISBN: 0253-9756 PMID: 9772677 Document Number: 463153
AIM: To study the effects of the combination of aspirin (Asp) and nifedipine (Nif) on mesenteric microcirculation of rats. METHODS: Acute microcirculation disturbance (AMD) was produced by high molecular weight dextran ( M-r 480 000, 360 mg cntdot kg-1 iv). Arteriole and venule blood flow velocity and diameter (ABFV, VBFV, AD, VD) and blood flow state (BFS) were observed by intravital microcirculation method. RESULTS: Asp 2.5, 5 mg cntdot kg-1, Nif 0. 05, 0. 1 mg cntdot kg-1, Asp + Nif (1 + 0.025), (2.5 + 0.05) mg cntdot kg-1, iv had the significant increase of 11.1%, 31.3%, 18.5%, 19.3%, 30.5%, 39.8% of ABFV and 12.5%, 25.7%, 12.6%, 15.2%, 29.6%, 36.1% of VBFV respectively, the marked improvement of BFS, and the distinctive increase of 4.3%, 17.9%, 35.9%, 39.7%, 15.2%, 42.8% of AD and 2.2%, 4.2%, 26.2%, 27.4%, 3.4%, 28.9% of VD separately, and got a raise in the number of capillaries. Asp + Nif (1 + 0.025), 2.5 + 0.05) mg cntdot kg-1 iv could reverse AMD. CONCLUSION: Asp was superior to Nif in the increase of BFV, but Nif was superior to Asp in expansion of blood vessel. Asp in combination with Nif produced marked synergistic action and protection against AMD.