Biochemical and physicochemical characterization of mouse B cell growth factor: a lymphokine distinct from interleukin 2
Farrar, J.J.; Howard, M.; Fuller-Farrar, J.; Paul, W.E.
Journal of Immunology 131(4): 1838-1842
1983
ISSN/ISBN: 0022-1767 PMID: 6352806 Document Number: 219962
A subline of the C57BL/6 mouse EL-4 thymoma produces on stimulation with phorbol myristate acetate (PMA) a B cell growth factor (BCGF) that co-stimulates anti-IgM-stimulated splenic B cells. The BCGF present in the EL-4 thymoma culture supernatants is shown to be distinct from IL 2 gel electrophoresis under nonreducing conditions (IL 2 is 21,000; BCGF is 11,000 and 15,000). The biologic activity of IL 2 is sensitive to trypsin inactivation as is BCGF activity. BCGF and IL 2 appear to be biologically and biochemically distinct glycoproteins.
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