Isolation and partial characterization of human T-cell growth factor
Böhlen, P.; Esch, F.; Wegemer, D.; Salk, P.; Dennert, G.
Biochemical and Biophysical Research Communications 117(2): 623-630
1983
ISSN/ISBN: 0006-291X PMID: 6607052 Document Number: 211010
Human T-cell growth factor (TCGF) was isolated from conditioned media of the Jurkat T-leukemia cell line. Using a high-efficiency isolation procedure involving hollow fiber concentration, gel filtration and 3 steps of reverse-phase HPLC DNA sequence coding for this protein. jTCGF is highly active in vitro in stimulating the proliferation of T-cells as measured by 3H-thymidine incorporation into DNA (half-maximal stimulation with 3 fmol/100 .mu.l well).
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