Peak blood levels of mepivacaine following intravenous regional anesthesia using various concentrations
Eckstein, K.L.; Rogacev, Z.; Grahovac, Z.; Vicente-Eckstein, A.
Regional-Anaesthesie 6(2): 23-26
1983
ISSN/ISBN: 0171-1946 PMID: 6675064 Document Number: 214930
In a previous study we assumed, that with I.V.R.A. the peak blood levels after opening the tourniquet would be less when lowering the concentration and simultaneously increasing the volume of the anesthetic solution. For supporting this hypothesis, on 17 patients each the peak blood levels of mepivacaine after I.V.R.A. were determined. For this a 0.25% (gr. A) and 0.50% (gr. B) concentration of solution was given. The same absolute amount (3.75 mg/ml b.w.) of the anesthetic was used and the measured values are compared. The results show a median for the 0.25% solutions of XA = 4,046 ng/ml and for the 0.50% ones of XB = 6,894 ng/ml. The values differ for p less than 0.05 with the onesided mediantest. Our initial assumption is confirmed which consequently contributes to greater safety.