Effect of naloxone in traumatic shock
Iasnetsov, V.V.; Motin, V.G.
Biulleten' Eksperimental'noi Biologii i Meditsiny 96(12): 50-52
1983
ISSN/ISBN: 0365-9615 PMID: 6661548 Document Number: 213518
Experiments on rabbits were made to examine the effect of naloxone, a specific antagonist of opiates and endogenous opioid peptides, on traumatic shock. Naloxone (0.1-1.0 mg/kg) injected intravenously 2-15 minutes after trauma produced no effect on the arterial pressure and the heart rate. As compared with control animals, the lifespan of animals with trauma decreased. It is suggested that endogenous opioid peptides may play a protective and adaptive role in the torpid phase of traumatic shock.