Effects of naloxone in hemorrhagic shock
Albert, S.A.; Shires, G.T.; Illner, H.; Shires, G.T.
Surgery Gynecology and Obstetrics 155(3): 326-332
1982
ISSN/ISBN: 0039-6087 PMID: 7112361 Document Number: 188996
The endorphins appear to play an integral role in the physiopathology of hemorrhagic shock. Blockade of these endodgenous opiates by naloxone can significantly alter the course of this syndrome. While the administration of naloxone to normal rats had no effect upon the circulation or cellular function, it improved the hemodynamic status of rats subjected to hemorrhagic shock, resulting in improved tissue perfusion. In addition, the administration of this drug prevented the cellular dysfunction normally seen in hemorrhagic shock. This effect was independent of its salutary effects upon the circulation.