Effects of promethazine on hemorrhagic shock in the dog
Goetsch, D.D.; Wilson, R.C.; Huber, T.L.
American Journal of Veterinary Research 43(12): 2193-2195
1982
ISSN/ISBN: 0002-9645 PMID: 7165163 Document Number: 188172
The effects of pre- and post-treatment with promethazine, an antihistamine, in hemorrhage-shocked dogs were investigated. Survival to 6 h was enhanced in the dogs given the H1-receptor antagonist i.m. 1 before hemorrhage was induced when compared with survivals of saline-treated control dogs (3 of 5 vs. 1 of 5 dogs). Of 5 dogs given promethazine i.v. 30 min after the initial hemorrhage, 4 survived. Promethazine treatment by either route increased mean arterial pressure among surviving dogs throughout the 6 h experimental period. Histamine actions on H1 receptors may be one of the factors affecting the ultimate outcome of severe hemorrhagic shock in dogs and promethazine may be of value in blocking these adverse histamine effects.