Extrachromosomal circular copies of an 'inter-Alu' unstable sequence in human DNA are amplified during in vitro and in vivo ageing
Shmookler Reis, R.J.; Lumpkin, C.K.; McGill, J.R.; Riabowol, K.T.; Goldstein, S.
Nature 301(5899): 394-398
1983
ISSN/ISBN: 0028-0836 PMID: 6823315 Document Number: 212118
A DNA sequence situated in the human genome between Alu-repeat clusters (inter-Alu DNA) is progressively amplified in extrachromosomal DNA, including covalently closed DNA circles, during serial passage of diploid fibroblasts. A single-size class of inter-Alu circles is also amplified in lymphocytes from 9 old donors and yet is not detected in cells from 8 young donors.
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