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Oxidation of p-aminophenol catalyzed by horseradish peroxidase and prostaglandin synthase

Josephy, P.D.; Eling, T.E.; Mason, R.P.

Molecular Pharmacology 23(2): 461-466

1983

ISSN/ISBN: 0026-895X
PMID: 6300652
Document Number: 211885
p-Aminophenol oxidation is catalyzed by horseradish peroxidase. ESR spectroscopy demonstrates the formation of the p-aminophenoxy free radical, the one-electron oxidation product of p-aminophenol. The same radical is formed by alkaline autoxidation of this compound. The ultimate products of p-aminophenol oxidation are mainly polymeric; however, indophenol was isolated in low yield. Oxidation of p-aminophenol is also catalyzed by the hydroperoxidase activity of prostaglandin synthase, using ram seminal microsomal preparations as the enzyme source.

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