Persistence of Rickettsia prowazekii with different initial biological properties in infected cotton rats

Ignatovich, V.F.; Barkhatova, O.I.; Rydkina, E.B.

Acta Virologica 27(6): 528-532

1983


ISSN/ISBN: 0001-723X
PMID: 6140840
Document Number: 211689
Evidence has been obtained indicating the association of certain biological properties of Rickettsia prowazekii with their capacity for persistence. Highly virulent rickettsial cultures inducing increased levels of complement-fixing antibodies were shown to cause a high percentage of rickettsial carriers in infected cotton rats. Within an interval of 133-189 days after inoculation with the virulent Breinl strain, rickettsial carrier-state was still demonstrable in 20% of the animals. The vaccine strain E of R. prowazekii had a low capacity for persistence in cotton rats, because 64 days after inoculation all animals were found free of rickettsiae.

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