Suppression of T cell cytotoxicity by nude mouse spleen cells: reversal by monosaccharides and interleukin 2
Palladino, M.A.; Ranges, G.E.; Scheid, M.P.; Oettgen, H.F.
Journal of Immunology 130(5): 2200-2202
1983
ISSN/ISBN: 0022-1767 PMID: 6220084 Document Number: 211581
The effects of monosaccharides on the suppression of cytotoxic T cell generation by spleen cells from nu/nu mice were examined. Suppression of the B6 anti-BALB/c response and the B6 anti-C3H response was reversed by alpha-methyl-D-galactoside (alpha MG) but not other sugars, including beta MG. Suppression was associated with a decrease in the level of IL 2, which suggests competition; this decrease was also reversed by alpha MG.
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