Migration of hepatic macrophages after cyclophosphamide or whole body irradiation
Castaldi, G.; Orzincolo, C.; Bariani, L.; Franceschini, F.; Di Lascio, B.; del Borrello, E.; Malacarne, P.
Bollettino della Societa Italiana di Biologia Sperimentale 59(5): 596-602
1983
ISSN/ISBN: 0037-8771 PMID: 6349663 Document Number: 211580
The liver macrophages behaviour after cyclophosphamide or total-body irradiation (1000 rads - 60Co) has been studied in the mouse previously injected with colloidal carbon. In these conditions an early increase of carbon-laden macrophages in the central zone of the liver lobules has been observed. Carbon-containing mononuclear cells were also observed in the lumina of the hepatic collecting system. Possible implications of these findings are discussed; a migration of macrophages from the liver to elsewhere is suggested.