Cyclophosphamide and cortisone acetate inhibit complement biosynthesis by guinea pig bronchoalveolar macrophages
Pennington, J.E.; Matthews, W.J.; Marino, J.T.; Colten, H.R.
Journal of Immunology 123(3): 1318-1321
1979
ISSN/ISBN: 0022-1767 PMID: 469252 Document Number: 144258
To explore mechanisms of drug-induced alterations in local host defenses in the lung, the capacity of guinea pig alveolar macrophages to synthesize the second (C2) and fourth (C4) components of complement was studied following treatment with cyclophosphamide and cortisone acetate. Administration of either drug significantly inhibited biosynthesis of C2 and C4 within 1 day. After 1 week of treatment, local complement synthesis was inhibited approximately 80%, although serum levels of the corresponding proteins were normal.