Compared efficacy of quinidine, GABA and N-trimethyl GABA upon a model of ventricular automaticity
Serrano, J.S.; Hernández, J.; Miñaño, J.
Methods and Findings in Experimental and Clinical Pharmacology 5(4): 251-254
1983
ISSN/ISBN: 0379-0355 PMID: 6888087 Document Number: 201536
The effects of GABA, its quaternary derivative N-trimethyl GABA and quinidine have been studied in a model of ventricular automaticity induced in the isolated right ventricle of the rat. GABA shows low anti-automatic activity. N-trimethyl GABA and quinidine were, however, very effective drugs in the reduction of the automatic ventricular rate. The efficacy of the latter two drugs at 5 X 10(-5) M was not significantly different. We conclude that N-trimethyl GABA has some anti-automatic activity in this experimental model, similar to a classic antidysrhythmic drug such as quinidine, that would warrant further research.